Star resident Dr. Conrad Hawkins continues to make difficult calls in the best interests of his patients. But, having rekindled a romantic relationship with nurse Nicolette "Nic" Nevin, the two must face unresolved issues from their past. Conrad's father, Marshall Winthrop, has taken over as head of Chastain, and comes into direct conflict with the hospital's newly minted CEO, Dr. Randolph Bell. Meanwhile, Dr. Mina Okafor continues to work with her larger-than-life mentor, Dr. AJ Austin. However, the skills of new ortho surgeon Dr. Kitt Voss could lead Mina on a difficult path. First-year resident Dr. Devon Pravesh becomes intrigued by a new medical device rep, whose presence at the hospital will upend business as usual for everyone there.