A small town sheriffs' department has to deal with an outbreak of murderous, infected people called "sickos." Cherry Darling meets up again with her old lover, El Wray, just as their Texas town is being overrun by "sickos" with festering sores turning them into zombies. Cherry has El Wray's jacket, which she took with her when she left and he keeps trying to explain how he looked for it for two weeks and she keeps interrupting his story. Gun-legged Cherry and one-man wrecking crew El Wray try to save the world from a horde of flesh-eating zombies.