For newlyweds Carl and Molly Peterson, life is sweet. With a nice house and established careers, nothing seems to get in the newlyweds way. However, Carl's best friend, Dupree, has just been displaced from his home and fired from his job because of attending their wedding. Taking his friend in for what should just be a few days, turns into a lot more than they bargained for. Especially when Dupree overstays his welcome and in causes one hilarious catastrophe after another for his newlywed hosts.